Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation

No skin irritation study is available for L-methionine.

The dermal irritation of D,L-methionine was investigated with rabbits in a GLP study according to OECD guideline 404 (2001 -0082 -DGT). There was no indication of a systemic effect of the treatment. The single application (4 hours, semi-occlusive patch) of 0.5 g D,L-methionine to the intact skin of each of three rabbits doesn’t show any substance related change at the examination time-points 60 minutes, 24, 48, and 72 hours after patch removel. Therefore, D,L-methionine can be regarded as not skin irritating.

Read-across of the D,L-methionine study to L-methionine can be applied due to structural and physico-chemical similarities according to Reach regulation (Annex XI, 1.5). Further, L-methionine is present in a considerable amount in racemic methionine (approximatly 50%). The remaining 50% (D-methionine) contain the same set of functional groups and is not believed to have specific cell damaging/irritating properties. Taking this into account it can be concluded that D,L-methionine has the same skin irritation properties as L-methionine.

Therefore, based on the results of the read-across substance D,L-methionine, L-methionine can be regarded/classified as not skin irritating.

This is supported by the so-called BfR rulebase. Due to the physicochemical exclusion rules for skin irritation L-methionine is judged to be not classified as R34, R35, or R38 (rule: CNS group with melting point > 120°C).

Eye irritation

No eye irritation study is available for L-methionine.

The eye irritation potential of D,L-methionine was investigated with rabbits in a GLP study according to OECD guideline 405 (2001 -0084 -DGT). There was no indication of a systemic effect of the treatment. A single application of 100 mg D,L-methionine per animal into the conjunctival sac of the eye of three rabbits caused conjunctival redness (grade 1) in all animals 1 hour after instillation. The cornea and iris were not affected by instillation of the test compound. Based on this result D,L-methionine can be regarded as not eye irritating.

Read-across of the D,L-methionine study to L-methionine can be applied due to structural and physico-chemical similarities according to Reach regulation (Annex XI, 1.5). Further, L-methionine is present in a considerable amount in racemic methionine (approximatly 50%). The remaining 50% (D-methionine) contain the same set of functional groups and is not believed to have specific cell damaging/irritating properties. Taking this into account it can be concluded that D,L-methionine has the same eye irritation properties as L-methionine.

Therefore, based on the results of the read-across substance D,L-methionine, L-methionine can be regarded/classified as not eye irritating.

This is supported by the so-called BfR rulebase. Due to the physicochemical exclusion rules for eye irritation L-methionine is judged to be not classified as R36 (rule: CNS group with melting point > 200°C).

Justification for classification or non-classification