Registration Dossier
Registration Dossier
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EC number: 200-562-9 | CAS number: 63-68-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicity of individual essential amino acids and their diastereomers in rats and the effect of blood sugar levels
- Author:
- GULLINO P, WINITZ M, BIRNBAUM SM, CORNFIELD J, OTEY MC, GREENSTEIN JP
- Year:
- 1 955
- Bibliographic source:
- Arch.Biochem.Biophys. 1955 Sep;58(1):253-5.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The compounds were administered singly as slurries in 5 ml. distilled water intraperitoneally into adult male rats.
The relation between dose and mortality was determined in three separate steps with increasingly narrower ranges of dosages at each successive step. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- L-methionine
- EC Number:
- 200-562-9
- EC Name:
- L-methionine
- Cas Number:
- 63-68-3
- Molecular formula:
- C5H11NO2S
- IUPAC Name:
- L-methionine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 180-250 g
- Fasting period before study:24h
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 29 other: mM/kg
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 328 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
