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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May - June 1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
L-methionine
EC Number:
200-562-9
EC Name:
L-methionine
Cas Number:
63-68-3
Molecular formula:
C5H11NO2S
IUPAC Name:
L-methionine

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: males 38 days, female 42 days
- Weight at study initiation: 100 - 106 g
- Fasting period before study: 15 - 16 h before application of test material
- Housing: individually
- Water: ad libitum


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24°C +/- 0.5°C
- Humidity (%): 60% +/- 3%

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: carboxy äthylcellulose gel 1%
Details on oral exposure:
VOLUME APPLIED: 25 mL/kg b.w.
Doses:
6.35, 7.90 and 10.0 g/kg b.w.
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 4 weeks

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Mortality:
no mortality occured
Clinical signs:
other: no clinical signs observed
Gross pathology:
no effects observed

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met