Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 284-660-7
CAS number: 84961-70-6
This study determined the effects of the test substance on reproductive
parameters. Groups of rats were exposed by oral gavage to concentrations
of 0, 250, 500 or 1000 mg/kg/day of test substance. Males were exposed
daily for 39 days, and females were exposed daily through lactation day
4. Animals were observed regularly for body weight, mortality, clinical
signs, food consumption, and behaviour. At the end of the study, the
animals were sacrificed and examined for gross pathology, organ weights,
histopathology, clinical chemistry, hematology, and urinalysis. In
addition, each litter was evaluated for viability at least twice daily
and clinical observations once daily. Each litter was counted once
daily. Pup weights were recorded on lactation days 1 and 4 for litters
of dams assigned to the main study hematology and clinical chemistry
portion of the study. Pup body weights were also recorded periodically
for various purposes. There were no significant effects to reproductive
parameters. The NOAEL for reproduction in rats is 1000 mg/kg/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again