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EC number: 284-660-7
CAS number: 84961-70-6
Results of Skin Irritation Study
This study examined the potential of the test substance to cause
irritation to skin. The test substance was placed on the skin of 6 male
rabbits for 4 hrs, and covered with a semi-occlusive patch. After 4 hrs,
the test substance was removed with warm water. The animals were scored
for signs of edema and erythema according to the Draize scale at 3/4,
24, 48, and 72 hrs. Because symptoms were not fully resolved at the end
of 72 hrs, the study was extended through 10 days after exposure. Signs
of erythema (maximum score of 2) and edema (maximum score of 2) were
seen at the 3/4 hr observation. These symptoms were fully resolved by
the day 8 observation. Signs of discoloration, drying and cracking were
seen starting at the 72 hr observation. By the day 10 observation, all
of these symptoms were resolved as well. The primary irritation index
was 1.25, and all symptoms were fully reversible. The test substance is
therefore not classified as a skin irritant according to EU GHS
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