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EC number: 284-660-7
CAS number: 84961-70-6
- atrophy, focal [total]
- cyst(s), ultimobrancial
- hypertrophy/hyperplasia, follicular [total]
Body Weight (g)
- Day 1
345.9 ± 8.6
346.4 ± 8.9
346.9 ± 8.4
345.6 ± 6.5
- Day 39
525.6 ± 45.0
489.0 ± 37.9
501.5 ± 31.7
478.8 ± 20.6
This study determined the sub-chronic toxicity of the test substance to
rats. Groups of rats were exposed by oral gavage to concentrations of 0,
250, 500 or 1000 mg/kg/day of test substance. Males were exposed daily
for 39 days, and females were exposed daily through lactation day 4.
Animals were observed regularly for body weight, mortality, clinical
signs, food consumption, and behaviour. At the end of the study, the
animals were sacrificed and examined for gross pathology, organ weights,
histopathology, clinical chemistry, hematology, and urinalysis
parameters. Adverse effects were seen in the thymus at all dose levels,
however, these changes are most likely stress related and are considered
to be of minimal toxicological significance. Body weight reduction was
seen in male rats at the 1000 mg/kg/day dose level. The LOAEL for male
rats is 1000 mg/kg/day, and the NOAEL is 500 mg/kg/day. No adverse
effects were seen in female rats. The NOAEL for female rats is 1000
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