Registration Dossier

Administrative data

Endpoint:
neurotoxicity: oral
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Non-GLP report without accordance to any guideline.

Data source

Reference
Reference Type:
publication
Title:
Anticonvulsant drugs. V. Some cyanurates.
Author:
Spielman, M.A.; Close, W.J.; Wilk, I.J.
Year:
1951
Bibliographic source:
J. Am. Chem. Soc., 73 (4), pp 1775–1777

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Details on test animals and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Any other information on results incl. tables

The test substance showed complete anticonvulsant protection in mice (provoked by electroshock or metrazol) but with some alterations in normal behaviour such as ataxia or depression.

Applicant's summary and conclusion