Registration Dossier
Registration Dossier
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EC number: 200-875-0 | CAS number: 75-50-3
Guidance on Safe Use
Administrative data
First-aid measures
Description of first aid measures
First aid personnel should pay attention to their own safety. If the patient is likely to become unconscious, place and transport in stable sideways position (recovery position). Immediately remove contaminated clothing.
If inhaled:
Keep patient calm, remove to fresh air, seek medical attention. Immediately administer a corticosteroid from a controlled/metered dose inhaler.
On skin contact:
Immediately wash thoroughly with plenty of water, apply sterile dressings, consult a skin specialist.
On contact with eyes:
Immediately wash affected eyes for at least 15 minutes under running water with eyelids held open, consult an eye specialist.
On ingestion:
Immediately rinse mouth and then drink 200-300 ml of water, seek medical attention.
Most important symptoms and effects, both acute and delayed
Symptoms: Information, i.e. additional information on symptoms and effects may be included in the GHS labeling phrases available in Section 2 and in the Toxicological assessments available in Section 11., Further symptoms are possible
Indication of any immediate medical attention and special treatment needed
Treatment: Treat according to symptoms (decontamination, vital functions), no known specific antidote. Pulmonary odema prophylaxis. Medical monitoring for at least 24 hours.
Fire-fighting measures
Extinguishing media
Suitable extinguishing media:
water spray, dry powder
Unsuitable extinguishing media for safety reasons:
water jet
Special hazards arising from the substance or mixture
Endangering substances: carbon monoxide, Carbon dioxide, toxic gases/vapours, nitrous gases
Advice: The substances/groups of substances mentioned can be released in case of fire.
Advice for fire-fighters
Special protective equipment:
Wear self-contained breathing apparatus and chemical-protective clothing.
Further information:
Suppress gases/vapours/mists with water spray jet. Containers/tanks should be cooled with water spray. Dispose of fire debris and contaminated extinguishing water in accordance with official regulations.
Accidental release measures
Personal precautions, protective equipment and emergency procedures
Avoid all sources of ignition: heat, sparks, open flame. Avoid contact with eyes. Ensure adequate ventilation. Use breathing apparatus if exposed to vapours/dust/aerosol. Keep people away and stay on the upwind side. Avoid skin contact. Take off immediately all contaminated clothing.
Environmental precautions
Discharge into the environment must be avoided. Suppress gases/vapours/mists with water spray jet. Retain and dispose of contaminated wash water. Due to the pH-value of the product, neutralization is generally required before discharging sewage into treatment plants.
Methods and material for containment and cleaning up
For small amounts: Pick up with suitable appliance and dispose of.
For large amounts: Pick up with suitable appliance and dispose of.
Avoid sources of ignition. Take precautionary measures against static discharges. Suppress gases/vapours/mists with water spray jet. Collect waste in suitable containers, which can be labeled
and sealed.
Handling and storage
Precautions for safe handling
Ensure thorough ventilation of stores and work areas. Refill and handle product only in closed system. Sealed containers should be protected against heat as this results in pressure build-up. Provide good room ventilation even at ground level (vapours are heavier than air). In closed rooms provide exhaust ventilation at floor level.
Protection against fire and explosion:
Substance/product can form explosive mixture with air. Prevent electrostatic charge - sources of ignition should be kept well clear - fire extinguishers should be kept handy.
Conditions for safe storage, including any incompatibilities
Segregate from acids and acid forming substances.
Further information on storage conditions: Keep container tightly closed in a cool, well-ventilated place. Avoid all sources of ignition: heat, sparks, open flame. Protect from direct sunlight.
Storage class according to TRGS 510 (originally VCI, Germany): (2A) Gases (except aerosol dispensers and lighters)
Storage stability:
Storage temperature: <= 35 °C
Storage duration: 24 Months
From the data on storage duration in this safety data sheet no agreed statement regarding the warrantee of application properties can be deduced.
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
Control parameters
Components with occupational exposure limits
The surveillance of the workplace by exposure measurements may be necessary, in order to proof the efficiency of safety measures, for example ventilation or the need of respiratory protection. Since this requires a specific competency, only accredited laboratories should be contracted. Regarding suitable methods to assess inhalative exposure the European Standards EN 482, 689 and 14042 are to be considered. In addition the TRGS 402 has to be observed in Germany.
75-50-3: Trimethylamine
Short Term Exposure Factor: (TRGS 900 (DE))
Ceiling limit value/factor: 2
Substance listed with exceeding factor and category of short time value.
Short Term Exposure Classification: (TRGS 900 (DE))
Category I: Substances for which the localized effect has an assigned exposure limit or for substances with a sensitizing effect in respiratory passages
TWA value 4,9 mg/m3 ; 2 ppm (OEL (EU))
indicative
STEL value 12,5 mg/m3 ; 5 ppm (OEL (EU))
indicative
OEL 4,9 mg/m3 ; 2 ppm (TRGS 900 (DE))
Ceiling limit value/factor: 2.5
If the occupational exposure limit value (AGW) and the biological limit value (BGW) are complied with, there should be no risk of damage for the unborn child (see TRGS 900, Number 2.7)
PNEC
freshwater: 0,078 mg/l
marine water: 0,0078 mg/l
intermittent release: 0,28 mg/l
sediment (freshwater): 0,328 mg/kg
sediment (marine water): 0,0328 mg/kg
soil: 0,0197 mg/kg
STP: 149,82 mg/l
oral (secondary poisoning):
No PNEC oral derived, as accumulation in organisms is not to be expected.
DNEL
worker:
Long-term exposure- systemic effects, Inhalation: 3,94 mg/m3
A qualitative risk assessment has been performed.
worker:
Long-term exposure - local effects, Inhalation: 4,9 mg/m3
The value corresponds to a BOELV A qualitative risk assessment has been performed.
worker:
Short-term exposure - local effects, Inhalation: 9,8 mg/m3
The value corresponds to a BOELV A qualitative risk assessment has been performed.
Exposure controls
Personal protective equipment
Respiratory protection:
Breathing protection if gases/vapours are formed. Suitable respiratory protection for higher concentrations or long-term effect: Self-contained breathing apparatus. Suitable respiratory protection for lower concentrations or short-term effect: Gas filter for gases/vapours of alkaline compounds such as ammonia, amines (e.g. EN 14387 Type K).
Hand protection:
Chemical resistant protective gloves (EN ISO 374-1)
Suitable materials also with prolonged, direct contact (Recommended: Protective index 6, corresponding > 480 minutes of permeation time according to EN ISO 374-1):
nitrile rubber (NBR) - 0.4 mm coating thickness
fluoroelastomer (FKM) - 0.7 mm coating thickness
Suitable materials against splashes (recommended: At least protective index 1, corresponding > 10 minutes of permeation time according to EN ISO 374-1)
butyl rubber (butyl) - 0.7 mm coating thickness
Supplementary note: The specifications are based on tests, literature data and information of glove manufacturers or are derived from similar substances by analogy. Due to many conditions (e.g. temperature) it must be considered, that the practical usage of a chemical-protective glove in practice may be much shorter than the permeation time determined through testing.
Eye protection:
Tightly fitting safety goggles (splash goggles) (e.g. EN 166)
Body protection:
full protection suit with breathing-air supply (f.e. according to EN 943)
General safety and hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wearing of closed work clothing is required additionally to the stated personal protection equipment. Avoid contact with the skin, eyes and clothing. Avoid inhalation of vapour. The substance was registered as a transported isolated intermediate. The manufacturer/importer has received the confirmation by the user that the substance is used under strictly controlled conditions in accordance with art. 18 of the REACH regulation (EC) No 1907/2006. When using, do not eat, drink or smoke. Hands and/or face should be washed before breaks and at the end of the shift. Gloves must be inspected regularly and prior to each use. Replace if necessary (e.g. pinhole leaks). Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Store work clothing separately.
Stability and reactivity
Reactivity
No hazardous reactions if stored and handled as prescribed/indicated.
Vapours may form explosive mixture with air.
Corrosion to metals:
No corrosive effect on metal.
Formation of flammable gases:
Remarks:
Study scientifically not justified.
Chemical stability
The product is stable if stored and handled as prescribed/indicated.
Possibility of hazardous reactions
Strong exothermic reaction with acids.
Conditions to avoid
Avoid all sources of ignition: heat, sparks, open flame.
Incompatible materials
Substances to avoid:
acids
Hazardous decomposition products
Possible thermal decomposition products:
toxic gases/vapours
Disposal considerations
Waste treatment methods
Incinerate in suitable incineration plant, observing local authority regulations.
A waste code in accordance with the European waste catalog (EWC) cannot be specified, due to dependence on the usage.
The waste code in accordance with the European waste catalog (EWC) must be specified in cooperation with disposal agency/manufacturer/authorities.
Contaminated packaging:
Contaminated packaging should be emptied as far as possible; then it can be passed on for recycling after being thoroughly cleaned.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
