Registration Dossier
Registration Dossier
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EC number: 200-875-0 | CAS number: 75-50-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to algae.
Key value for chemical safety assessment
Additional information
The toxicity of trimethylamine (CAS 75-50-3) to aquatic algae and cyanobacteria was studied in a GLP-guideline study following OECD 201. The test was performed under static conditions, using Pseudokirchneriella subcapitata as test organism. The nominal test concentrations were analytically verified. The study was performed by the Ministry of the Environment (MOE of Japan) in 2011.
The data of the original report were re-evaluated using ToxRat v2.10 in order to obtain an EC10, which is not originally reported. According to REACH Guidance document chapter R.10 Table R.10-1 (Overview of toxicity test endpoints and guidance on derivation of L(E)C50 and NOEC values) an EC10 for a long-term test which is obtained using an appropriate statistical method (usually regression analysis) will be used preferentially.
There has been a recommendation within OECD in 1996 to phase out the use of the NOEC, in particular as it can correspond to large and potentially biologically important magnitudes of effect. The advantage of regression method for the estimation of ECx is that information from the whole concentration-effect relationship is taken into account and that confidence intervals can be calculated. These methods result in an ECx, where x is a low effect percentile (e.g. 5-20%). It makes results from different experiments more comparable than NOECs. The recalculation fulfills the required validity criteria.
The 72 -h ErC50 was >100 mg/L (nominal). The 72 -h ErC10 was determined to be 88.6 mg/L (nominal). These values were selected as key data.
Supporting experimental data are available from an non-GLP guideline study, performed according to DIN 38412, part 9 without analytical monitoring (BASF AG, 1988). Desmodesmus subspicatus was used as test organism. Based on nominal test concentrations, the 72 -h ErC50 was 150 mg/L. The 72 -h ErC10 was determined to be 86 mg/L.
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