Registration Dossier
Registration Dossier
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EC number: 200-875-0 | CAS number: 75-50-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish.
Key value for chemical safety assessment
Additional information
In the Key study conducted by the Ministry of the Environment in Japan (MOE, 2011) using Oryzias latipes as test organism, a 96-h LC50 of > 100 mg/L (based on nominal test concentrations) was determined for Trimethylamine. The semi-static limit test was performed according to OECD 203.
In a supporting study, Trimethylamine was tested in its neutralized as well as in its non-neutralized form. Leuciscus idus was used as test organism. When neutralized, a LC50 of 610 mg/L (nominal) was obtained, whereas if not, a 48-h LC50 of 25 mg/L is reported (Bayrisches Landesamt für Wasserwirtschaft, 1989), indicating that the lower effect concentration determined for non-neutralized test solutions is mainly due to the pH. In a further supporting study Oryzias latipes was used in a static freshwater test with an exposure duration of 48 hours. A LC50 value of 1000 mg/L is given as result (Tonogai et.al., 1982).
In order to choose the most critical value, the 96-h LC50 of > 100 mg/L (MOE, 2011) was selected as key data for the chemical safety assessment.
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