Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-046-7 | CAS number: 10025-87-3
Carcinogenicity
Administrative data
Description of key information
“No carcinogenicity studies with phosphoryl trichloride in experimental animals were identified in the available literature. As phosphoryl trichloride hydrolyzes quickly to form hydrochloric and phosphoric acids, chronic effects are expected mostly from exposure to these degradation products” (OECD SIDS for phosphoryl trichloride, 2004).
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Phosphoryl trichloride hydrolyzes quickly to form hydrochloric and phosphoric acid. “The resulting anions chloride and phosphate are essential components of every living tissue. They are not expected to produce mutagenic effects” (OECD SIDS for phosphoryl trichloride, 2004). A classification is therefore not justified.
Additional information
“In water, phosphoryl trichloride hydrolyzes to phosphoric acid and hydrochloric acid with t1/2 < 10 seconds (Riess, 2002): POCl3+ 3 H2O→H3PO4+ 3 HCl” (OECD SIDS for phosphoryl trichloride, 2004).
“The hydrolysis product hydrochloric acid gave no indications for an increased tumor incidence after life-time exposure in laboratory animals. Data on phosphoric acid, the second hydrolysis product, are not available, but no specific effects are expected. At low concentrations the hydrolysis products, phosphoric and hydrochloric acid, will be neutralised immediately in the physiologic medium at the portal of entry” (OECD SIDS for phosphoryl trichloride, 2004).
“The resulting anions chloride and phosphate are essential components of every living tissue. They are not expected to produce mutagenic effects. The reduced pH levels could lead to chromosomal changes and DNA damage at the portal-of-entry of phosphoryl trichloride. However, it is unlikely that systemic changes in pH would occur after exposure to phosphoryl trichloride, that are sufficient in magnitude to induce this effect in distant tissues or organs. Nevertheless prolonged irritation could give rise to a constant stimulus to cell proliferation” (OECD SIDS for phosphoryl trichloride, 2004).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
