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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Summary reported in limited detail, but sufficient for classification

Data source

Reference
Reference Type:
publication
Title:
Comparative toxicity of the chloride compounds of phosphorus (POCl3, PCl3, PCl5) in single and repeated exposures.
Author:
Molodkina NN
Year:
1974
Bibliographic source:
Toksikologiya Novykh Promyshlennykh Khimichesrikh Veshchestv, 13, 107-114

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A single dose was administered into the conjunctival sac.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phosphoryl trichloride
EC Number:
233-046-7
EC Name:
Phosphoryl trichloride
Cas Number:
10025-87-3
Molecular formula:
Cl3OP
IUPAC Name:
phosphoroyl trichloride

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No additional information

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No information given
Duration of treatment / exposure:
No information given
Observation period (in vivo):
None specified
Number of animals or in vitro replicates:
No information given
Details on study design:
A single installation of phosphoryl trichloride was added into the conjunctional sac of the rabbit eye.

Results and discussion

In vivo

Results
Irritation parameter:
other: not reported due to the severity of the reactions
Basis:
mean
Time point:
other: all
Score:
100
Max. score:
100
Reversibility:
not reversible
Remarks on result:
other: Theoretical maximum scores. Actual scores are not reported due to irreversible corrosion and necrosis.
Irritant / corrosive response data:
Limited information given in study report, but it was observed that an irreversible necrotic process developed which led to loss of vision
Other effects:
Corrosive effects were seen under the conditions of this study

Any other information on results incl. tables

An irreversible necrotic process was observed, that developed and led to a loss of vision

Applicant's summary and conclusion

Interpretation of results:
other: corrosive
Conclusions:
Severe corrosive effects were seen under the conditions of this study.
Executive summary:

Severe corrosive effects were seen under the conditions of this study. Exposure to phosphoryl trichloride caused an irreversible necrotic process which resulted to the loss of vision.