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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011-07-19 to 2011-08-02
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study is regarded as reliable without restrictions because it was conducted in compliance with GLP regulation and is scientifically well documented and complete in any part.
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
April 2004
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Version / remarks:
May 2008
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Version / remarks:
August 1996
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
> 6.5
Temp.:
25 °C
pH:
6.2
Remarks on result:
other: The extrapolated log Pow value calculated for 1,1'-(1,1,2,2-tetramethylethylene)dibenzene: 6.68
Key result
Type:
log Pow
Partition coefficient:
6.68
Temp.:
25 °C
pH:
6.2
Remarks on result:
other: extrapolated from the measured data
Details on results:
The partition coefficient Pow was determined based on a calibration curve using seven reference items. The capacity factors k were calculated from the dead time and the retention times of the reference substances. The log k data of the reference substances were plotted against their log Pow values. From this correlation graph of the reference items, the partition coefficient of the test item was extrapolated.
Conclusions:
The retention time of 1,1'-(1,1,2,2-tetramethylethylene)dibenzene is higher than the last eluting reference item. Thus, the log Pow of the test item was estimated to be > 6.5. The extrapolated log Pow value calculated for the test item was 6.68.
Executive summary:

The partition coefficient of 1,1'-(1,1,2,2-tetramethylethylene)dibenzene was determined according to EU method A.8, OECD Guideline 117, and EPA OPPTS 830.7570 guideline. Using the HPLC method the partition coefficient log Pow of the test item was determined to be > 6.5. The estimated log Pow of the test item is 6.68 at 25 °C.

Description of key information

The retention time of 1,1'-(1,1,2,2-tetramethylethylene)dibenzene is higher than the last eluting reference item. Thus, the log Pow of the test item was estimated to be > 6.5. The extrapolated log Pow value calculated for the test item was 6.68.

Key value for chemical safety assessment

Log Kow (Log Pow):
6.68
at the temperature of:
25 °C

Additional information

The partition coefficient of 1,1'-(1,1,2,2-tetramethylethylene)dibenzene was determined according to EU method A.8, OECD Guideline 117, and EPA OPPTS 830.7570 guideline. Using the HPLC method the partition coefficient log Pow of the test item was determined to be > 6.5. The estimated log Pow of the test item is 6.68 at 25 °C.