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EC number: 217-568-2
CAS number: 1889-67-4
In a bacterial reverse mutation assay (Ames
test) the mutagenic potential of
1,1'-(1,1,2,2-tetramethylethylene)dibenzene was investigated in the
Salmonella typhimurium strains TA 98, TA 100, TA 1535 and TA1537 with
and without liver microsomal activation. Each concentration, including
the controls, was tested in triplicate. The test article was tested at
33.3; 100.0; 333.3; 1000.0; 2500.0 and 5000.0 µg/plate. The test was
performed according to OECD 471 and Regulation (EC) 84/449/EEC Method
No toxic effects occurred in the test
article groups with and without metabolic activation in two independent
experiments in all strains used. The plates incubated with the test
article showed normal background growth up to 5000.0 µg/plate with and
without S9 mix in all strains used.
No substantial increases in revertant colony
numbers of any of the four tester strains were observed following
treatment with the test item at any dose level in the presence or
absence of metabolic activation (S9 mix). There was also no tendency of
higher rates with increasing concentrations in the range below the
generally acknowledged border of significance.
Appropriate reference mutagens were used as
positive controls and showed a distinct increase in induced revertant
In conclusion, it can be stated that under
the experimental conditions of a reverse mutation assay (Ames test),
1,1'-(1,1,2,2-tetramethylethylene)dibenzene did not induce point
mutations by base pair changes or frameshifts in the genome of four
Salmonella typhimurium strains. Therefore,
1,1'-(1,1,2,2-tetramethylethylene)dibenzene is considered to be
non-mutagenic in the Salmonella typhimurium reverse mutation assay.
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