Registration Dossier
Registration Dossier
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EC number: 246-309-6 | CAS number: 24549-06-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary citation
Data source
Reference
- Reference Type:
- secondary source
- Title:
- ECB (2000): Ethyl Corporation, unpublished data, 1970.
- Author:
- European Commission - European Chemicals Burean
- Year:
- 2 000
- Bibliographic source:
- ECB (2000): Ethyl Corporation, unpublished data, 1970.
Materials and methods
- Principles of method if other than guideline:
- Method: other: acute dermal toxicity
- GLP compliance:
- no
- Test type:
- other: acute dermal toxicity
Test material
- Reference substance name:
- 6-ethyl-2-toluidine
- EC Number:
- 246-309-6
- EC Name:
- 6-ethyl-2-toluidine
- Cas Number:
- 24549-06-2
- Molecular formula:
- C9H13N1
- IUPAC Name:
- 2-ethyl-6-methylaniline
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4 (IUCLID dataset, 2000)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- other: undiluted test article was injected onto the skin under plastic sleeves fitted around the animal
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- up to 14 days (unspecified)
- Doses:
- 830, 1300, 2000, 3100 mg/kg bw
- No. of animals per sex per dose:
- 4 animals per dose group
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 290 mg/kg bw
Any other information on results incl. tables
RS-Freetext:
No deaths occurred at 0.83 grams per kilogram.
Two animals died in the 1.3 gram/kg group on days 4 and 14.
All animals died at 2.00 and 3.10 gram/kg within 3 days of
dosing. Animals showed definite color change at 24 hours
indicative of cyanosis.
LD50 values were 1.29 grams/kilogram with
95% confidence limits of 1.00 to 1.66 grams per kilogram.
Applicant's summary and conclusion
- Executive summary:
In an acute dermal toxicity study with New Zealand rabbits a LD50 value of ca.1290 mg/kg bw was calculated (ECB 2000).
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