Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-309-6 | CAS number: 24549-06-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Different toxicokinetic studies with rats showed that MEA is readily absorbed independent of the application route (ECB 2000 b). The test substance is readily taken up into the general circulation and is rapidly excreted, mainly with the urine (76% to 93 %) (ECB 2000 a, ECB 2000 b, Marco 1985).
Key value for chemical safety assessment
Additional information
Different toxicokinetic studies with rats showed that 2 -methyl-6-ethylaniline (MEA) is readily absorbed independent of the application route (ECB 2000 b). The test substance is readily taken up into the general circulation and is rapidly excreted, mainly with the urine (76% to 93 %) (ECB 2000 a, ECB 2000 b, Marco 1985). One major urine metabolic metabolite was identified as the sulfate ester conjugate of 2-ethyl-4-hydroxy-6-methyl aniline. Only a minority of the test substance is eliminated in the feces (2-6%) (ECB 2000 b, Marco1985). About 5 %, 2 %, and less than 1 % of the dose applied remained in or on the animal after dermal (48 hours), inhalation (48 hours) and oral (72 hours) application (ECB 2000 b). The recovery of the test substance in the tissues was highest in livers, kidneys, blood components, fat, adrenals and thyroids. No apparent sex difference in blood content and excreta of the test substance were found (ECB 2000 a).
Discussion on bioaccumulation potential result:
Different toxicokinetic studies with rats showed that MEA is readily absorbed independent of the application route (ECB 2000 b). The test substance is readily taken up into the general circulation and is rapidly excreted, mainly with the urine (76% to 93 %) (ECB 2000 a, ECB 2000 b, Marco 1985). One major urine metabolic metabolite was identified as the sulfate ester conjugate of 2-ethyl-4-hydroxy-6-methyl aniline. Only a minority of the test substance is eliminated in the feces (2-6%) (ECB 2000 b, Marco1985). About 5 %, 2 %, and less than 1 % of the dose applied remained in or on the animal after dermal (48 hours), inhalation (48 hours) and oral (72 hours) application (ECB 2000 b). The recovery of the test substance in the tissues was highest in livers, kidneys, blood components, fat, adrenals and thyroids. No apparent sex difference in blood content and excreta of the test substance were found (ECB 2000 a).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
