Registration Dossier
Registration Dossier
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EC number: 246-309-6 | CAS number: 24549-06-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: number of animals not given, several substances were investigated and necropsy results cannot be related to a respective substance, no histopathological examinations were performed
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute oral toxicity of mono- and di-alkyl ring-substituted derivatives of aniline. short communication.
- Author:
- Jacobson, K., H.
- Year:
- 1 972
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 22, 153-154 (1972)
- Reference Type:
- publication
- Title:
- Acute oral toxicity of 2-alkyl- and 2,6-dialkylanilines. Correlation with lipophilicity
- Author:
- Durden jr, J. A.
- Year:
- 1 973
- Bibliographic source:
- J. Med. Chem. vol. 16, no. 11, 1316
Materials and methods
- Principles of method if other than guideline:
- Method: other: acute toxicity, unspecified
- GLP compliance:
- not specified
- Test type:
- other: acute toxicity, unspecified
Test material
- Reference substance name:
- 6-ethyl-2-toluidine
- EC Number:
- 246-309-6
- EC Name:
- 6-ethyl-2-toluidine
- Cas Number:
- 24549-06-2
- Molecular formula:
- C9H13N1
- IUPAC Name:
- 2-ethyl-6-methylaniline
- Details on test material:
- IUCLID4 Test substance: other TS: 2-methyl-6-ethylaniline, no data on purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 820-1690 mg/kg bw (no further information)
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 180 mg/kg bw
Any other information on results incl. tables
RS-Freetext:
LD 50 = 1180 mg/kg body weight
95 % confidence limit: 820 - 1690 mg/kg bw
Signs of intoxication (not specified for o-toluidine, several aniline derivates were tested:
Severely intoxicated rats were lethargic, cyanotic (bluish coloration of lower limbs and of mouth and nose), and showed enlarged spleens, darkened organs and blood.
Applicant's summary and conclusion
- Executive summary:
In male Sprague-Dawley rats an oral LD50 from 1180 mg/kg body weight was determined.
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