Registration Dossier
Registration Dossier
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EC number: 416-210-4 | CAS number: 128119-70-0
Endpoint summary
Administrative data
Description of key information
Bioaccumulation test on aquatic species is predicted based on the fact that the available information (log Kow and calculated BCF values) is deemed sufficient for the PBT assessment, classification and labelling and the chemical safety assessment for this Annex VIII registration and the marketed tonnages of this substance being between 10 -100 tpa. Bioaccumulation for aquatic and terrestrial organisms were calculated using QSARs of Veith et al. (1979) and Jager (1998), both incorporated in the EUSES model, and yielded values of 381 and 87.8 L/kg ww, respectively.
Bioaccumulation in air-breathing organisms: The substance fulfils the screening criteria for bioaccumulation of air-breathing organisms when using the Koa predictor of EpiSuite. When using the Log Pblood-air partition coefficient the criteria are not met because the value is 4.0, which is < 5 (Koa cut off). In addition, the substance is metabolised (OECD Toolbox and Xenosite) and is excreted via the kidneys as seen in the male rat. Therefore there is no bioaccumulation in air-breathing organisms.
Additional information
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