Praseodymium trinitrate

Endpoint summary

Description of key information

Acute toxicity - oral:
A K2 acute oral toxicity test was performed in female Sprague-Dawley rats according to a guideline similar to OECD Guideline 401 (Bruce DW, 1963). This study was selected as key study. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

No data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Sufficiently documented acute oral toxicity study in female rats performed according to a method equivalent to OECD Guideline 401.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: No data
- Age at study initiation: adult
- Weight at study initiation: 190 g to 250 g
- Fasting period before study: no data
- Housing: Animals were housed in air-conditioned quarters
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
50% aqueous solution

Doses:

unknown

No. of animals per sex per dose:

5 or 10 animals per group

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 30 days

Statistics:

On the basis of the mortality that occurred during the 30-day observation period, the LD50 values with 95% confidence limits were calculated by the method of Litchfield and Wilcoxon (1949).

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

3 500 mg/kg bw

Based on:

test mat.

95% CL:

3 017 - 4 060

Mortality:

The animals were observed for 30 days although no deaths occurred later than 4 days after administration of the nitrate salts by the oral route.

Clinical signs:

other: Within 1 to 2 hours after oral administration of the rare earth nitrates most of the rats were depressed, and animals that received lethal doses showed little activity during the survival period.

Gross pathology:

Throughout the observation period no gross pathologic changes were noted.

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral LD50 of praseodymium nitrate in female rats was determined to be 3500 mg/kg. The test substance is considered not classified according to the criteria of the CLP Regulation.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

3 500 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Acute toxicity: oral

Bruce DW (1963) investigated the acute oral toxicity via gavage of a single oral dose of praseodymium nitrate in 5 to 10 female Sprague-Dawley rats. The animals were observed for 30 days although no deaths occurred later than 4 days after administration. Within 1 to 2 hours after oral administration of the rare earth nitrates most of the rats were depressed, and animals that received lethal doses showed little activity during the survival period. Throughout the observation period no gross pathologic changes were noted. The acute oral LD50 of praseodymium nitrate in female rats was determined to be 3500 mg/kg.

No data were available for the inhalation and dermal route.

Justification for classification or non-classification

Based on the results of the acute oral toxicity study and according to the criteria of the CLP Regulation, praseodymium trinitrate should not be classified as an acute oral toxicant.

No data were available to decide on the classification for the inhalation and dermal route.