3,6,9-trioxaundecane-1,11-diol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not specified but between 9 Dec 1985 and 6 April 1986

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The report does not specify about GLP/Guideline but sufficient data is available for interpretation of results

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

3,6,9-trioxaundecane-1,11-diol

EC Number:

203-989-9

EC Name:

3,6,9-trioxaundecane-1,11-diol

Cas Number:

112-60-7

Molecular formula:

C8H18O5

IUPAC Name:

2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethan-1-ol

Test material form:

liquid: viscous

Details on test material:

Tetraethylene glycol (Sample No.; 48-349) was obtained from Union Carbide Corporation, Texas City, TX.

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

Male or female rabbits may be used. The animals are maintained on appropriate commercial diet and municipal water.

Test system

Type of coverage:

semiocclusive

Preparation of test site:

clipped

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

0.5 ml

Duration of treatment / exposure:

4 hr

Observation period:

10 days.

Number of animals:

6

Details on study design:

Male or female New Zealand White rabbits are dosed with 0.5 ml. The dose is applied to the clipped, intact skin under a gauze patch and is loosely covered with impervious sheeting. The test material is applied to each of 6 rabbits, which are restrained for the 4-hr contact period. Excess sample is removed after contact. Skin reaction is scored, by the method of Draize, at one hour, one day, 2 days, 3 days, 7 days, and 10 days after dosing.

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: 1 hr post dosing

Score:

0

Max. score:

0

Remarks on result:

other: same score observed after 1, 2, 3, 7 and 10 days.

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

other: 1 hr post dosing

Score:

0

Max. score:

0

Remarks on result:

other: same score observed after 1, 2, 3, 7 and 10 days.

Irritant / corrosive response data:

There was no erythema, eschar and edema observed in any of the rabbits exposed for 4 hours for tetraethylene glycol.

Other effects:

There were no other effects noted in rabbits exposed for 4 hours for tetraethylene glycol.

Any other information on results incl. tables

No additional information available.

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

A 4-hour application of tetraethylene glycol to covered rabbit skin resulted in no irritation.

Executive summary:

The effects of 4 hour dermal exposure of tetraethylene glycol to rabbit skin was examined. There was no irritation or any other effects noted in rabbits dermally exposed to tetraethylene glycol for 4 hours.