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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Although the study conducted was not in accordance to any guideline/s and GLP, there is sufficient data to permit meaningful evaluation of the study results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
no guideline available

Test material

Constituent 1
Reference substance name:
2,2'-oxydiethanol
EC Number:
203-872-2
EC Name:
2,2'-oxydiethanol
Cas Number:
111-46-6
IUPAC Name:
2,2'-oxydiethanol
Radiolabelling:
yes

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: methanol
Duration of exposure:
15 minutes, 64 minutes, 8 hours and 24 hours
No. of animals per group:
4 rats received 75 µl of diethylene glycol in methanol

Results and discussion

Total recovery:
Cryostat sectioning showed that diethylene glycol is absorbed through the skin of rats based on percent of radioactivity remaining in the dosed area, which was 47.2, 32.6, 29.2 and 16.8 per cent after contact times of 15 minutes, 64 minutes, 8 hours and 24 hours, respectively.

Applicant's summary and conclusion

Conclusions:
Cryostat sectioning showed that diethylene glycol is absorbed through the skin of rats based on percent of radioactivity remaining in the dosed area, which was 47.2, 32.6, 29.2 and 16.8 per cent after contact times of 15 minutes, 64 minutes, 8 hours and 24 hours, respectively. After 15 minutes post dermal administration of diethylene glycol, a radioactive peak appeared ~ 112 microns into the skin. Percent of radioactivity in the urine after contact times of 8 and 24 hours was 11.9 and 32.2 per cent, respectively