3,6,9-trioxaundecane-1,11-diol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not specified but between 9 Dec 1985 and 6 April 1986

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The report does not specify about GLP/Guideline but sufficient data is available for interpretation of results

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,6,9-trioxaundecane-1,11-diol

EC Number:

203-989-9

EC Name:

3,6,9-trioxaundecane-1,11-diol

Cas Number:

112-60-7

Molecular formula:

C8H18O5

IUPAC Name:

2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethan-1-ol

Test material form:

liquid: viscous

Details on test material:

Tetraethylene glycol was obtained from Texas City, TX plant (sample # 48-349). No further details provided.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Sprague-Dawley albino rats, weighing between 200 and 300 g, were used.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

The vapor is produced by passing air (at 2.5 liters/min) through the sample and then through a 9-liter animal chamber (dynamic conditions).

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

6 h

Concentrations:

Described as substantially saturated vapor generated at 24C.

No. of animals per sex per dose:

5 males and 5 females

Control animals:

not specified

Details on study design:

Rats were weighed prior to exposure to the test material and again on day 7 and 14. Animals were observed for clinical symptoms and mortality. At the end of the 14 day observation period, a gross pathologic examination of the rats was conducted.

Statistics:

Body weight mean and S.D. were calculated.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

0.06 ppm

Based on:

test mat.

Exp. duration:

6 h

Mortality:

No mortality was observed in males or females exposed to a substantially saturated vapor concentration.

Clinical signs:

other: No clinical signs were observed in males or females exposed to a substantially saturated vapor concentration.

Body weight:

Male rats gained weight on days 7 and 14 from pre-exposure values (Table 1). Females remained essentially the same throughout the 14 day observation period.

Gross pathology:

There were no treatment-related gross pathologic observations.

Other findings:

Using a vapor pressure of 0.0000465 mm Hg at 25C corresponds to a saturated vapor concentration of 0.061 ppm.

Any other information on results incl. tables

Table 1 Body weights of Males and Females exposed to a substantially saturated vapor concentration for 6 hours.

	Day 0	Day 7	Day 14
Males	237 + 2.4	261 + 5.7	282 + 7.9
Females	256 + 7.2	257 + 8.9	256 + 8.4

Applicant's summary and conclusion

Conclusions:

A single dynamic inhalation exposure to substantially saturated vapor for a 6-hour period produced no deaths or other signs of toxicity among male and female rats.

Executive summary:

Groups of 5 male and 5 female rats were exposed to a substantially saturated vapor concentration for 6 hours. There were no effects on mortality, body weight, clinical symptoms or gross pathology noted in rats.