3,6,9-trioxaundecane-1,11-diol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not specified but between 9 Dec 1985 and 6 April 1986

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The report does not specify about GLP/Guideline but sufficient data is available for interpretation of results

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method B.1 (Acute Toxicity (Oral))

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,6,9-trioxaundecane-1,11-diol

EC Number:

203-989-9

EC Name:

3,6,9-trioxaundecane-1,11-diol

Cas Number:

112-60-7

Molecular formula:

C8H18O5

IUPAC Name:

2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethan-1-ol

Test material form:

other: Colorless, transparent, viscous liquid

Details on test material:

Sample was received from UCC Texas City, Texas plant. No information on test chemical purity provided in report.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Sprague-Dawley albino rats, weighing between 200 and 300 g were used. The rats are fasted overnight before dosing.

The animals are maintained on appropriate commercial diet and municipal water. Both are available ad libitum except during periods of fasting (rat peroral test) or manipulation.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

The maximum dosage for the peroral test is 16 ml/kg. Based on the test results, no additional dose levels were examined.

Doses:

16 ml/kg

No. of animals per sex per dose:

5 males and 5 females.

Control animals:

not specified

Details on study design:

Animal weights are recorded at 0 days (before dose), 7 days and 14 days (just prior to sacrifice). At death or sacrifice, each animal is subjected to gross pathologic evaluation.

Statistics:

LD50's and the estimated LD50 slopes are calculated by the moving average method (Thompson, 1947; Weil, 1983) and are based on a 14-day observation period.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 16 mL/kg bw

Based on:

test mat.

Mortality:

None of 5 males or 5 females died from this dosage.

Clinical signs:

other: There were no signs of toxicity observed.

Gross pathology:

There were no remarkable gross pathologic lesions observed.

Other findings:

No additional information available.

Any other information on results incl. tables

No additional information available.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 for male and female rats receiving single peroral doses of tetraethylene glycol was greater than 16.0 ml/kg (>18000 mg/kg).

Executive summary:

The acute oral toxicity of tetraethylene glycol was examined.

The LD50 for male and female rats receiving single peroral doses of tetraethylene glycol was greater than 16.0 ml/kg, Rats gained weight with no clinical signs of toxicity. There were no remarkable gross pathological lesions observed.