Registration Dossier
Registration Dossier
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EC number: 206-370-1 | CAS number: 333-20-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed pre-GLP and pre-guideline. Nevertheless it gives a good indication of dermal absorption for this substance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Absorption of some organic compounds through the skin in man
- Author:
- Feldmann, R.J., Maibach, H.I.
- Year:
- 1 970
- Bibliographic source:
- J Invest Dermatol (54)5 399-404
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- see materials and methods
- GLP compliance:
- no
- Remarks:
- pre-GLP
Test material
- Reference substance name:
- Potassium thiocyanate
- EC Number:
- 206-370-1
- EC Name:
- Potassium thiocyanate
- Cas Number:
- 333-20-0
- Molecular formula:
- CNS.K
- IUPAC Name:
- potassium thiocyanate
- Details on test material:
- Potassium thiocyanate, no further information.
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- human
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- acetone
- Duration of exposure:
- 24 hours
- Doses:
- 4 µg/cm2 on a 13 cm2 area
- No. of animals per group:
- 6
- Control animals:
- no
Results and discussion
Percutaneous absorption
- Dose:
- 4 µg/cm2
- Parameter:
- percentage
- Absorption:
- 10.15 %
- Remarks on result:
- other: 24 h
- Remarks:
- SD 6.60%
Any other information on results incl. tables
See attached table.
Applicant's summary and conclusion
- Executive summary:
The authors studied the percutaneous penetration of 21 organic chemicals. The experimental method consisted of the application of the chemical to the human forearm and quantitating its penetration through the skin by its appearance in urine. The recovery from after urine was 10.15% ± 6.60% of the administered dose for potassium thiocyanate, 4 µg/cm2 on a 13 cm2 area, after a collection period of 120 hours.
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