Potassium thiocyanate

Genetic toxicity: in vivo

Administrative data

Endpoint:

genetic toxicity in vivo

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

disregarded due to major methodological deficiencies

Study period:

no data

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: The study does not meet the current guideline and was not performed under GLP.

Data source

Reference

Reference Type:

publication

Title:

The antimutagenic effect of sodium thiocyanate on the mutagenicity of cyclophosphamide towards mouse bone-marrow cells and germ cells.

Author:

Kramer, A., Paldy, A., Wueffen, W., Berencsi, G.

Year:

1983

Bibliographic source:

Wissenschaftliche Zeitschrift der Ernst-Moritz-Arndt-Universitaet Greifswald, Medizinische Reihe, Vol 32, Issue 1-2, pp 69-71.

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

Ammonium thiocyanate

EC Number:

217-175-6

EC Name:

Ammonium thiocyanate

Cas Number:

1762-95-4

IUPAC Name:

ammonium thiocyanate

Applicant's summary and conclusion

Executive summary:

In examinations of the bone-marrow as well as germ cells of 2 strains of mice (ICR, CFLP) was found that NaSCN applied at a dose of 64 mg/kg daily on 3 consecutive days significantly decreases the frequency of the chromosome aberrations evoked by cyclophosphamide, from 68% to 52% in the bone-marrow cells ( α <1%) and from 25% to 16% in the germ cells (α < 5%). With regard to the medical and biological importance of the thiocyanates it seems promosing to subject these findings to a deeper treatment.