Registration Dossier
Registration Dossier
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EC number: 206-370-1 | CAS number: 333-20-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Aqueous solutions of Thiocyanates salts of ammonium, sodium or potassium, are fully dissociated. Consequently, with no specific concerns for the kations (NH4+, Na+ and K+), are studies on one of the thiocyanate substances NH4SCN, NaSCN or KSCN fully applicable for the evaluation of the other substances.
Ammonium thiocyanate was negative in the Ames test. Sodium thiocyanate is negative in an in vitro chromosome aberration study and an in vitro mammalian mutagenicity study. All studies followed adequate OECD and EU protocols and were performed under GLP. Consequently, thiocyanates are considered to be non-genotoxic.
Justification for selection of genetic toxicity endpoint
For each endpoint bacterial mutagenicity, mammalian mutagenicity and mammalian clastogenicity a GLP compliant study is available.
Short description of key information:
Ammonium thiocyanate was negative in the Ames test. Sodium thiocyanate is negative in an in vitro chromosome aberration study and an in vitro mammalian mutagenicity study. These results indicate that thiocyanates are not genotoxic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Aqueous solutions of Thiocyanates salts of ammonium, sodium or potassium, are fully dissociated. Consequently, with no specific concerns for the kations (NH4+, Na+ and K+), are studies on one of the thiocyanate substances NH4SCN, NaSCN and KSCN fully applicable for the evaluation of the other substances.
Tests have shown these thiocyanates salts to be negative in an Ames test, in an in vitro chromosome aberration study and in an in vitro mammalian mutagenicity study. Classification for thiocyanate is therefore not warranted.
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