Registration Dossier
Registration Dossier
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EC number: 239-635-5 | CAS number: 15578-26-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Ditin pyrophosphate
- EC Number:
- 239-635-5
- EC Name:
- Ditin pyrophosphate
- Cas Number:
- 15578-26-4
- Molecular formula:
- H4O7P2.2Sn
- IUPAC Name:
- ditin pyrophosphate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino rabbit
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 1,5 g
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 7 days
- Number of animals:
- 3
- Details on study design:
- 1,5 g of Tin(II) purophosphate were applied to one intact skin site for each animal. All sites were pre-moisterd with water with water. The entire hair-slipped part of each animal was then covered with an impervious sleeve for a skin contact period of 24 hours. The animals were observed for 7 days after treatment.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- None of the intact skin sites was affected.
Applicant's summary and conclusion
- Conclusions:
- Tin(II) pyrophosphate is not classified for skin irritation according to Regulation (EC) n. 1272/2008 criteria
- Executive summary:
1,5 g of Tin(II) purophosphate were applied to one intact skin site for 3 albino rabbits. The entire hair-slipped part of each animal was then covered with an impervious sleeve for a skin contact period of 24 hours. The animals were observed for 7 days after treatment. None of the intact skin sites was affected.
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