Registration Dossier
Registration Dossier
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EC number: 239-635-5 | CAS number: 15578-26-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
Test material
- Reference substance name:
- Ditin pyrophosphate
- EC Number:
- 239-635-5
- EC Name:
- Ditin pyrophosphate
- Cas Number:
- 15578-26-4
- Molecular formula:
- H4O7P2.2Sn
- IUPAC Name:
- ditin pyrophosphate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Aqueous solution 2%
- Doses:
- 1600 mg/kg
2263 mg/kg
3200 mg/kg
4526 mg/kg
6400 mg/kg - No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 805 mg/kg bw
- 95% CL:
- >= 2 844 - <= 5 021
- Clinical signs:
- General distress, prolonged diarrhea, anorexia
- Body weight:
- Losses in body weight required 3 to 16 days for restoration
- Gross pathology:
- Autopsies revealed possible Kidney and adrenal pathology and occasional hematuria
Applicant's summary and conclusion
- Conclusions:
- Tin(II) pyrophosphate is not classified for oral toxicity according to Regulation (EC) n. 1272/2008 criteria.
- Executive summary:
An aqueous suspension (2%) of the sample, was administrated by stomach tube to rats. Surviving animal were observed untill lost body weight was recovered.
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