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Short-term toxicity to aquatic invertebrates

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Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
27 September 1995 to 29 September 1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
no
GLP compliance:
yes
Analytical monitoring:
no
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Test temperature:
20 ± 2 °C
pH:
- pH 7.8 to 7.9 (0 h)
- pH 7.8 to 8.2 (48 h)
Nominal and measured concentrations:
Nominal concentrations of 0.30, 0.60, 1.25, 2.5, 5.0 and 10 mg/L
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
1.2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Conclusions:
The 48 hour EC50 value of Lakeland ACP 70 to Daphnia magna was estimated as 1.2 mg/L.
Executive summary:

The 48 hour EC50 value of Lakeland ACP 70 to Daphnia magna was estimated as 1.2 mg/L. The highest no-observed effect concentration (HNEC) after 48 hours was 0.60 mg/I. The lowest test concentration which immobilised all twenty Daphnia (LOEC) within 48 hours was 2.5 mg/I. Water quality measurements of the test solutions were within acceptable limits. None of the twenty control Daphnia, maintained in dilution water, was immobilised during the study and this indicates an acceptable level of health of the test organisms cultured under the test conditions.

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
other: ISO 14669 (Water quality - determination of acute lethal toxicity to marine copepods (Copepoda, Crustacea)
Version / remarks:
1999(E)
Deviations:
no
GLP compliance:
yes
Analytical monitoring:
no
Test organisms (species):
other: Acartia tonsa
Test type:
static
Water media type:
saltwater
Limit test:
no
Total exposure duration:
48 h
Test temperature:
Not reported
pH:
Not reported
Nominal and measured concentrations:
Nominal concentrations of 0.1 to 1.0 mg/L
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
0.1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Conclusions:
Exposure of Acartia tonsa to the substance gave LC50 (48 h) 1.0 mg/L and the NOEC value was reported as 0.1 mg/L.
Executive summary:

A sample of ACP 70 was assessed for potential toxicity to the marine copepod Acartia tonsa in a static test over 48 hours according to the draft method ISO 14669: 1999(E). Nominal test concentrations of ACP 70 were prepared over the range 0.10 mg 1-1 to 1.0 mg/L. Acartia tansa were exposed to the test concentrations in order to determine the concentration which killed 50% of the copepods over 48 hours (LCSO). Results were reported as LC50 (48 h) 1.0 mg/L and the NOEC value was reported as 0.1 mg/L.

Description of key information

Results are available for one species of freshwater invertebrate and one species of marine invertebrate.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
1.2 mg/L
EC50/LC50 for marine water invertebrates:
1 mg/L

Additional information