Registration Dossier

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature source (documentation insufficient for assessment)
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
review article or handbook
Title:
Environmental and human safety of major surfactants, alcohol ethoxylates and alkylphenol ethoxylates
Author:
Talmage SS
Year:
1994
Bibliographic source:
Lewis publishers, CRC Press, Inc., 2000 Corporate Bld., N.W., Boca Raton, Florida 33431. ISBN 1-56670-017-5

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No data
Duration of exposure:
No data
Doses:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
No data
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Any other information on results incl. tables

No data

Applicant's summary and conclusion

Conclusions:
According to the test results, the dermal LC50 for NPE-4 was determined to be greater than 2,000 mg/kg bw.
Executive summary:

A study was conducted to evaluate the acute dermal toxicity of a commercial formulation of NPE-4 to rabbit. Under the study conditions, the dermal LD50 was > 2,000 mg/kg bw (Talmage SS, 1994).