Registration Dossier
Registration Dossier
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EC number: 201-069-1 | CAS number: 77-92-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study was not in accordance with guideline but provides information for effects of inhlatory exposure of animals to citric acid aerosols.
Data source
Reference
- Reference Type:
- publication
- Title:
- Citric acid induced cough
- Author:
- Forsberg & Karlsson
- Year:
- 1 986
- Bibliographic source:
- Bull.Eur.Physiopathol. Respir. 71s Clinical Repiratory Physiology
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- Citric acid
- EC Number:
- 201-069-1
- EC Name:
- Citric acid
- Cas Number:
- 77-92-9
- Molecular formula:
- C6H8O7
- IUPAC Name:
- 2-hydroxypropane-1,2,3-tricarboxylic acid
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- guinea pig
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Duration of exposure:
- 3 min
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: tussigenic potential
- Effect level:
- ca. 75 mg/L air
- Exp. duration:
- 3 min
- Remarks on result:
- other: The study reports the irritation potential of the test substance to airways, but does not contribute to acute inhalation toxicity
- Remarks:
- Citric acid aerosol, 0.93M produced 90 +/-1.9 coughs during 3 minute exposure.
Any other information on results incl. tables
Citric acid aerosol, 0.93M, 75 mg/ml produced 90 +/-1.9 coughs during 3 minute exposure.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
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