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EC number: 201-069-1
CAS number: 77-92-9
There are no long-term test data for fish. Testing is not considered
In accordance with Column 2 of REACH Annex IX, the requirement for
long-term toxicity data for aquatic invertebrates (required in Section
9.1.3) is waived on the grounds that the chemical safety assessment
indicates that it is not necessary.
In accordance with Column 2 of REACH Annex IX, the study does not need
to be conducted because the registrant has concluded based on the
following assessment of the chemical that long-term toxicity to fish is
unlikely to be observed:
- citric acid is essential in the Krebs cycle (or TCA cycle), which in
turn is an essential chemical cycle that takes place in all living
organisms to generate energy, via the generation of adenosine
triphosphate (ATP). This means that citric acid is naturally present
inside all living organisms and it is very unlikely that it will be
found in the environment at concentrations high enough to exert hazards
to organisms (see attached report);
- the short-term aquatic toxicity data indicate that citric acid is of
low toxicity, with EC50 and LC50 values >100 mg/L
for fish and invertebrates and a NOEC of 425 mg/L for algae. In
addition, citric acid has been used as a supplement in fish feed to
improve growth, mineral bioavailability and feed performance (Shah et
al. 2015). Therefore, long-term effects in studies conducted at standard
doses are considered to be unlikely;
- the substance is readily biodegradable, has a log Kow <3
and is highly soluble. Therefore, it is very unlikely to persist in the
environment long enough to cause long-term effects.
Overall, it is concluded that the risk characterisation conclusion is
sufficiently conservative in respect of any uncertainties and therefore
further testing is not considered necessary.
Shah, Syed Zakir & Afzal, Muhammad & Khan, Shafaat & Hussain, Syed &
Zeeshan, Rana. (2015). Prospects of Using Citric Acid as Fish Feed
Supplement. International Journal of Agriculture and Biology. 17. 1-8.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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