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EC number: 201-132-3 | CAS number: 78-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 11/11/1983 - 01/20/1984
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Significant metholdological deficiences.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups of 10 male and 10 female rats were exposed to dust atmospheres of VazoR 64 for single 1-hour periods. The purpose of this study was to determine the 1-hour LC50 for VazoR 64 in male and female rats.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- propanenitrile, 2,2'-azobis(2-methyl)-
- IUPAC Name:
- propanenitrile, 2,2'-azobis(2-methyl)-
- Reference substance name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- EC Number:
- 201-132-3
- EC Name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- Cas Number:
- 78-67-1
- Molecular formula:
- C8H12N4
- IUPAC Name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- Details on test material:
- Purity > 98%
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding laboratories, Kingston, NY
- Age at study initiation: 8-9 week old
- Weight at study initiation: 240-265 g (males), 161-181g (females)
- Fasting period before study: no data
- Housing: in pairs (sexes separate) in 8''x8''x14'' stainless steel, wire-mesh cages.
- Diet (e.g. ad libitum): Purina certified rodent chow #5002, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period:n 1 week
ENVIRONMENTAL CONDITIONS
- Temperature : 74+/-2°F
- Humidity (%): 50+/-10
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 1 h
- Concentrations:
- 1.57 , 3.40, 7.78 mg/L
- No. of animals per sex per dose:
- 10 animals/ sexe/dose
- Control animals:
- no
- Details on study design:
- All rats were weighed and observed daily for 2 weeks post exposure, except for the saturday and sunday of the second week post exposure.
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 7.78 mg/L air
- Exp. duration:
- 1 h
- Mortality:
- One male rat died one day after exposure to 1.57 mg/l of Vazo 64. No death occurred after exposure followed by a return to a normal weight gain rate.
- Clinical signs:
- other: About half of the rats showed wet or stained perineal areas for one to two days after exposure.
- Body weight:
- Most rats showed moderate to severe weight losses one or two days after exposure followed by a return to a normal weight gain rate.
Applicant's summary and conclusion
- Conclusions:
- LC50 was not determined with this study. During exposures, only 10% at most of the airborne dust was of respirable size (<10 µm aerodynamic diameter).
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