Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 273-227-8
CAS number: 68953-84-4
Dietary exposure to DAPD for 2 generations of rats
resulted in parental toxicity at 120, 400, & 1500 ppm. Polycystic
kidneys were present in F0 & F1 adults, and in F1 & F2 weanlings in all
treatment groups. The renal results for all populations in lowest
exposure group (120 ppm) exhibited only minimal polycystic changes.
Slight increases were seen in relative liver wts in parental F0 & F1
male high dose rats. Reproductive effects included a decreased
gestational index in the F0 generation at the high dose only, and
increased gestational lengths in the F0 (mid & high dose) and F1 (all
doses) deliveries. The number of total & live births per litter on
post-natal day 0 were diminished to a degree in all dose groups of the
F1 & F2 generations with statistical significance seen in the mid and
high dose F1 litters, and high dose F2 litter.
No reproductive toxicity was observed in males due to
chemical exposures. The most pronounced effects in females was delayed
parturition which may have been associated with the increased perinatal
mortality and decreased live births. This finding has been previously
observed for R-59 (N,N'-diphenyl-p-phenylene) in the published
literature. The NOEL for this study is <120 ppm dietary level.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Questo sito web si avvale di cookie affinché possiate usufruire della migliore esperienza sui nostri siti web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again