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Long-term toxicity to aquatic invertebrates

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Description of key information

1) Key: A long-term reproduction study with invertebrates (Daphnia magna) (21days) (K1) (OECD 211 & GLP) resulted in an EC10 (21days, reproduction) = 0.0045 mg/L (estimated by extrapolation).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.004 mg/L

Additional information

There is one test available which evaluates the long-term toxicity effects towards aquatic invertebrates (per GLP and OECD211)(Sacker, 2010). Waterfleas (Daphnia magna) were exposed to DAPD for 21 days in order to evaluate the effects of the substance on the reproductive output of the organisms. At the end of the test, the live offspring per parent Daphnia (alive) was evaluated. An EC10 (21 days; reproduction) of 0.0045 mg/L (estimated by extrapolation) was calculated and the lowest observed effect concentration (LOEC - reproduction) after 21 days was determined at 0.007 mg/L. In the same test the no observed effect value (NOEC) for parent Daphnia survival (21 days) was 0.016 mg/L, the EC10 (survival, 21 days) was 0.027 mg/L. .