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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Publication.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
monograph
Author:
Opdyke et al.
Year:
1982
Bibliographic source:
Food and Chemical Toxicology
Reference Type:
review article or handbook
Title:
Acute oral toxicity study of test chemical in rat
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials
Reference Type:
other: authoritative database
Title:
Acute oral toxicity by using test chemical
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
ChemIDplus
Reference Type:
publication
Title:
Aliphatic and Aromatic Ethers
Author:
WHO
Year:
2004
Bibliographic source:
The Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of the given test chemical was performed in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: (2-methoxyethyl)benzene
- InChI: 1S/C9H12O/c1-10-8-7-9-5-3-2-4-6-9/h2-6H,7-8H2,1H3
- Smiles: c1(ccccc1)CCOC
- Molecular formula :C9H12O
- Molecular weight:136.193 g/mole
- Substance type:organic
- Physical state:Colorless liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
Range of 3100-5500 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
4 100 mg/kg bw
Based on:
test mat.
95% CL:
3 100 - 5 500
Mortality:
50% mortality was observed at 4100 mg/kg bw in treated animals.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
Acute oral toxicity dose (LD50) value was considered to be 4100 mg/kg bw, with 95% confidence limits of 3100-5500 mg/kg bw, when male and female rats was treated with the given test chemical via oral route.
Executive summary:

Acute oral toxicity study was conducted by using the given test chemical in male and female rats at the dose concentration range of 3100-5500 mg/kg bw.

Animals were observed for mortality. 50% mortality was observed at 4100 mg/kg bw in treated animals.

Hence, the LD50 value was considered to be 4100 mg/kg bw, with 95% confidence limits of 3100-5500 mg/kg bw, when male and female rats was treated with the given test chemical via oral route.