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EC number: 204-640-3 | CAS number: 123-66-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-07-03 to 2015-07-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 508 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 5 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 30 °C
- pH:
- ca. 4.9
- Details on results:
- Preliminary test: The water solubility was determined to be in the range of 500-1000 mg/L
- Conclusions:
- The water solubility of the test item was determined to be 508 mg/L (pH 4.9) at 20 ± 0.5 °C.
- Executive summary:
The test item has a water solubility of 508 mg/L (pH 4.9) at 20 ± 0.5 °C as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).
Reference
Table: Water Solubility Results at 20 °C
Preincubation time [h] |
Replicate No. |
Test item |
|
Concentration |
Mean value |
||
24 |
1 |
467 |
500 |
2 |
503 |
||
48 |
1 |
528 |
523 |
2 |
518 |
||
72 |
1 |
493 |
502 |
2 |
512 |
||
Mean (24 - 72 h) |
|
508 |
|
Deviation [%] (24 - 72 h) |
4.60 |
||
Temperature at incubation phase, 30°C and thermostatisation phase, 20 °C (measured hourly
Intended temperature |
Measured temperature [°C] |
||
|
Min |
Max |
Mean value± SD |
30±0.5 |
29.91 |
30.08 |
30.00±0.02 |
20±0.5 |
20.04 |
20.17 |
20.08±0.02 |
PH value
Test temperature [°C] |
Pre-incubation time [h] |
replicate |
Measured pH |
Mean value |
20 |
24 |
1 |
4.770 |
4.9 |
2 |
4.852 |
|||
48 |
1 |
5.056 |
||
2 |
4.983 |
|||
72 |
1 |
4.967 |
||
2 |
4.970 |
|||
control |
6.437 |
- |
No tyndall effect was detected during the incubation time .
Validity criteria were fullfilled: The concentration measured did not differ more than 15%, tempreatures were kept constant within ± 0.5°C
Description of key information
The water solubility is 508 mg/L (pH 4.9) at 20 ± 0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 508 mg/L
- at the temperature of:
- 20 °C
Additional information
The test item has a water solubility of 508 mg/L (pH 4.9) at 20 ± 0.5 °C as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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