Registration Dossier
Registration Dossier
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EC number: 203-846-0 | CAS number: 111-21-7
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis is not considered to be a relevant abiotic degradation process. A base-catalysed second-order hydrolysis rate constant of 0.491 L/(mol-sec) was estimated using a structure estimation method. This corresponds to half-lives of 163.4 days at pH 7 and 16.3 days at pH 8.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 16.3 d
- at the temperature of:
- 25 °C
Additional information
No experimental studies investigating the abiotic hydrolysis of 2,2'-[ethane-1,2-diylbis(oxy)]bisethyl diacetate (CAS 111-21-7) are available. However, in accordance with Regulation (EC) No. 1907/2006, Annex VIII, column 2, testing is not required since the substance can be regarded as readily biodegradable. In addition, supporting (Q)SAR estimations indicate that hydrolysis is a negligible pathway for the environmental fate of the substance:
SPARC v4.5
A base-catalysed second-order hydrolysis rate constant (Kb) of 0.491L/(mol-sec) at 25 degC was estimated using a structure estimation method.
This corresponds to half-lives of 163.4 days at pH 7 and 16.3 days at pH 8.
HYDROWIN v2.00
A base-catalysed second-order hydrolysis rate constant (Kb) of 0.5264 L/(mol-sec) at 25 degC was estimated using a structure estimation method.
This corresponds to half-lives of 152.4 days at pH 7 and 15.2 days at pH 8.
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