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Physical & Chemical properties

Water solubility

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Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2001-01-29 to 2001-02-01
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: a method of Fa.BAYER AG
Deviations:
no
GLP compliance:
no
Type of method:
other: DOC method, according to DIN 38409 Part 3
Key result
Water solubility:
160 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 000 mg/L
Temp.:
20 °C
Remarks on result:
other: mean value
Water solubility:
177 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 000 mg/L
Incubation duration:
24 h
Temp.:
20 °C
Remarks on result:
other: no data on pH value
Water solubility:
142 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 000 mg/L
Incubation duration:
72 h
Temp.:
20 °C
Remarks on result:
other: no data on pH value
Details on results:
The test item concentration was measured after 24 and 72 h Test duration.
Conclusions:
The water solubility of the test item was determined to be 160 mg/L at 20±0.2 °C.
Executive summary:

A non-GLP-Study following the principles of GLP study was conducted according to a method of Fa. BAYER AG which is similar to OECD Guideline 105 for Testing of Chemicals (1995) to determine the water solubility of the test item. Two independent replicates of the test item in water were prepared by dissolving 100 mg test item in 100 mL water. The test item mixture was stirred for 24 h and 72h. After 24 and 72 h one replicate containing test item and one control replicate were filtered through 0.45 pm and analysed. The analytical quantification of the test item was carried out via analysis of dissolved organic carbon (DOC, according to DIN 38409 Part 3). The solubility of the test item was determined as mean of the 24-72 h time points to be 160 mg/L at 20 ±2 °C.

Description of key information

The water solubility of the test item was determined to be 160 mg/L at 20±0.2 °C.

Key value for chemical safety assessment

Water solubility:
160 mg/L
at the temperature of:
20 °C

Additional information

A non-GLP-Study following the principles of GLP study was conducted according to a method of Fa. BAYER AG which is similar to OECD Guideline 105 for Testing of Chemicals (1995) to determine the water solubility of the test item. Two independent replicates of the test item in water were prepared by dissolving 100 mg test item in 100 mL water. The test item mixture was stirred for 24 h and 72h. After 24 and 72 h one replicate containing test item and one control replicate were filtered through 0.45 pm and analysed. The analytical quantification of the test item was carried out via analysis of dissolved organic carbon (DOC, according to DIN 38409 Part 3). The solubility of the test item was determined as mean of the 24-72 h time points to be 160 mg/L at 20±2 °C.