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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 January 2002 to 19 March 2002
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
Cited as Directive 92/69/EEC, A.8
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
0.63
Temp.:
10 °C
pH:
7
Key result
Type:
log Pow
Partition coefficient:
0.7
Temp.:
20 °C
pH:
7
Key result
Type:
log Pow
Partition coefficient:
0.76
Temp.:
30 °C
pH:
7
Key result
Type:
log Pow
Partition coefficient:
0.99
Temp.:
20 °C
pH:
5
Type:
log Pow
Partition coefficient:
0.7
Temp.:
20 °C
pH:
7
Key result
Type:
log Pow
Partition coefficient:
-0.9
Temp.:
20 °C
pH:
9
Details on results:
The effects of temperature and pH were investigated
Conclusions:
The partition coefficients for BIT at a range of temperatures and pHs were found to be in the ranges 0.63 to 0.76 and -0.90 to 0.99 respectively.
Executive summary:

The partition coefficients for BIT at a range of temperatures and pHs were found to be in the ranges 0.63 to 0.76 and -0.90 to 0.99 respectively.

Description of key information

The partition coefficient was determined according to EU Method A.8 (Seal, 2002).

Key value for chemical safety assessment

Log Kow (Log Pow):
0.7
at the temperature of:
20 °C

Additional information