Registration Dossier
Registration Dossier
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EC number: 277-551-0 | CAS number: 73609-36-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
A Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test with triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane (CAS 51851-37-7) was included to this dossier for information only. The study was conducted according to the appropriate OECD Test Guideline 422 and in compliance with GLP. No adverse effects were observed on male and female fertility or fetus development at any dose tested.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
It is considered not to be either ethical or technically feasible to perform reproductive toxicity testing with [2-(perfluorohexyl)ethyl]dichloro(methyl)silane by any route of exposure at toxicologically relevant doses or concentrations due to its known corrosive properties.
Data on the structural analogue [2-(perfluorohexyl)ethyl]triethoxysilane are also available and they are included as supporting information but they are not considered further due to the fact that corrosion is the predominant effect and that oral exposure is not relevant to humans. In the Combined Repeated Dose Oral Toxicity Study with the Reproduction / Developmental Toxicity Screening Test, conducted according to an appropriate OECD test guideline and in compliance with GLP, the reported NOAEL value for reproductive toxicity for [2-(perfluorohexyl)ethyl]triethoxysilane was ≥125 mg/kg bw/day (the highest dose tested; Eurofins, 2017).
Effects on developmental toxicity
Description of key information
A Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test with triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane (CAS 51851-37-7) was included to this dossier for information only. The study was conducted according to the appropriate OECD Test Guideline 422 and in compliance with GLP. No adverse effects were observed on male and female fertility or fetus development at any dose tested.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
It is considered not to be either ethical or technically feasible to perform developmental toxicity testing with [2-(perfluorohexyl)ethyl]dichloro(methyl)silane by any route of exposure at toxicologically relevant doses or concentrations due to its known corrosive properties.
Data on the structural analogue [2-(perfluorohexyl)ethyl]triethoxysilane are available and are included as supporting information but they are not considered further due to the fact that corrosion is the predominant effect and that oral exposure is not relevant to humans. In this Combined Repeated Dose Oral Toxicity Study with the Reproduction / Developmental Toxicity Screening Test, conducted according to an appropriate OECD test guideline and in compliance with GLP, the reported NOAEL value for developmental toxicity for [2-(perfluorohexyl)ethyl]triethoxysilane was ≥125 mg/kg bw/day (the highest dose tested; Eurofins, 2017).
Justification for classification or non-classification
The available information on hydrogen chloride indicates that [2-(perfluorohexyl)ethyl]dichloro(methyl)silane does not require classification for reproductive or developmental toxicity according to Regulation (EC) No. 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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