Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 277-551-0 | CAS number: 73609-36-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 3rd 2002 to June 10th 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- dose levels differ from guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- dose levels differ from guideline
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- [2-(perfluorohexyl)ethyl]dichloro(methyl)silane
- IUPAC Name:
- [2-(perfluorohexyl)ethyl]dichloro(methyl)silane
- Reference substance name:
- Dichloro(methyl)(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
- IUPAC Name:
- Dichloro(methyl)(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
- Reference substance name:
- Dichloromethyl(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
- EC Number:
- 277-551-0
- EC Name:
- Dichloromethyl(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
- Cas Number:
- 73609-36-6
- Molecular formula:
- C9H7Cl2F13Si
- IUPAC Name:
- (dichloromethyl)(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
- Test material form:
- other: liquid
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- other: CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH, Sandhofer Weg 7, D-97633.
- Age at study initiation: male 41 days, female 48 days.
- Weight at study initiation: male (6 animals) 173-213 g; female (3 animals) 167-178 g.
- Fasting period before study: 16 hours before administration.
- Housing: Makrolon cages (type 3), 2-3 animals per cage. Granulated textured wood (Granulate A2, J. Brandenburg, D49424 Goldenstedt) was used as bedding material.
- Diet ssniff R/M-H V 1530 ad libitum.
- Water: drinking water ad libitum.
- Acclimation period: at least 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +/- 3°C
- Humidity (%): 55% +/- 15%
- Air changes (per hr): no information
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: April 2002 To: June 10th 2002
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: undiluted for highest dose; 10% for second dose level.
MAXIMUM DOSE VOLUME APPLIED: 1.29 ml/kg bw.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: none given in report. The dose used is the limit dose for EU acute oral classification. - Doses:
- 200, 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 male rats (2000 mg/kg bw); 3 male and 3 female (200 mg/kg bw).
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations were made before and immediately, at 5, 15, 30 and 60 minutes, then at 3, 6 and 24 hours after administration. All surviving animals were examined at daily intervals. Weights were recorded on days 0, 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight and macroscopic inspection of all animals that died prematurely; macroscopic examination of all survivors for gross pathological changes was carried out, and microscopic examination of all organs which showed evident lesions would have been performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The three male animals dosed with 2000 mg/kg bw died within 30 minutes. None of the 3 male and 3 female animals dosed with 200 mg/kg bw died.
- Clinical signs:
- other: 2000 mg/kg bw resulted in the following signs of systemic toxicity; reduced motility, ataxia, reduced muscle tone, dyspnoea. None of the 3 male and 3 female animals dosed with 200 mg/kg bw showed signs of systemic toxicity.
- Gross pathology:
- No abnormalities were found on macroscopic post mortem examination of the animals.
- Other findings:
- No effect dose level: 200 mg/kg bw.
Any other information on results incl. tables
Summary of results of acute toxicity study
Symptoms/criteria |
2000 mg/kg bw |
200 mg/kg bw |
||
male (n=3) |
male (n=3) |
female (n=3) |
||
Reduced motility |
++ to +++ 5 – 15 minutes |
- |
- |
|
Ataxia |
++ to +++ 5 – 15 minutes |
- |
- |
|
Reduced muscle tonus |
+ to ++ 5 – 15 minutes |
- |
- |
|
Dyspnoea |
++ to +++ 5 – 15 minutes |
- |
- |
|
Mortality |
within 6 hours |
3 |
0 |
0 |
within 14 days |
3 |
0 |
0 |
|
Mean weight |
Day 0 |
204.7 g |
181.7 g |
173.7 g |
Day 8 |
- |
232.0 g |
205.7 g |
|
Day 15 |
- |
236.0 g |
216.7 g |
|
Inhibition of body weight gain |
None |
None |
None |
|
Autopsy findings |
None |
None |
None |
+ slight
++ moderate
+++ severe
- not observed
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Toxicity Category IV by application of Regulation (EC) No 1272/2008
- Conclusions:
- [2-(Perfluorohexyl)ethyl]dichloro(methyl)silane has been tested for acute oral toxicity in an acute toxic class study conducted according to OECD 423 and in compliance with GLP. All of three male CD rats dosed with 2000 mg/kg bw of test substance died within 6 hours. The clinical signs observed in these animals were reduced motility, ataxia, reduced muscle tone and dyspnoea; there were no gross abnormalities observed on necropsy. There were no clinical signs, deaths or macroscopic abnormalities found in the three male and three female animals treated with 200 mg/kg bw. It was concluded that the LD₅₀ is between 200 and 2000 mg/kg bw. [2-(Perfluorohexyl)ethyl]dichloro(methyl)silane is hydrolytically unstable, with a hydrolysis half-life at 37.5ºC and pH 4 (relevant for conditions in the stomach following oral exposure), of approximately 5 seconds (predicted). Therefore it is considered that the animals would have been exposed to the hydrolysis products, [2-(perfluorohexyl)ethyl]methylsilanediol and hydrochloric acid, and that the effects observed reflect the properties of the hydrolysis products.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.