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EC number: 202-851-5 | CAS number: 100-42-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Ring-oxidized metabolites of styrene contribute to styrene-induced Clara-cell toxicity in mice.
- Author:
- Cruzan G, Carlson GP, Turner M, Mellert W.
- Year:
- 2 005
- Bibliographic source:
- J Toxicol Environ Health, Part A 68(3): 229-237
- Reference Type:
- review article or handbook
- Title:
- European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.
- Author:
- European Union
- Year:
- 2 007
- Bibliographic source:
- Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007
Materials and methods
- Principles of method if other than guideline:
- 4-Vinylphenol was administered intraperitoneally to rats for 14 consecutive days. After 14 days, the animals were necropsied and the liver and lungs were examined histopathologically.
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Styrene
- EC Number:
- 202-851-5
- EC Name:
- Styrene
- Cas Number:
- 100-42-5
- Molecular formula:
- C8H8
- IUPAC Name:
- ethenylbenzene
Constituent 1
- Specific details on test material used for the study:
- The substance tested is a metabolite of styrene.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: female: Charles River, Sulzfeld, Germany
- Age at study initiation: 5-6 weeks
- Weight at study initiation: 129-160 g
- Housing: in air conditioned rooms
- Diet (e.g. ad libitum): standard rodent diet (Purina 5001, Purina Milss, St. Louis, MO) or pellets (Provimi KLIBA SA, Kaiseraugst, Switzerland)
- Water (e.g. ad libitum): from water bottles
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24 °C
- Humidity (%): 30-70%
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- physiological saline
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- daily (doses are splitted into 3 daily doses; at intervals of 2 hours)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2, 6, 20, 60 mg/kg/day rat
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: daily
BODY WEIGHT: Yes
- Time schedule for examinations: study days 0, 3, 7 and 14
OPHTHALMOSCOPIC EXAMINATION: No
HAEMATOLOGY: No
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: on study days 1, 7 and 13
- Animals fasted: No data
- How many animals: 5
- Parameters checked: serum sorbitol dehydrogenase
URINALYSIS: No
NEUROBEHAVIOURAL EXAMINATION: No - Sacrifice and pathology:
- GROSS PATHOLOGY: No data
HISTOPATHOLOGY: Yes, liver and lungs - Statistics:
- body weight: Dunnett´s t-test with significant value of p< 0.05
serum sorbitol dehydrogenase: Kurskal-Wallis nonparametric test with significant value of p< 0.05
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Remarks:
- (4-VP)
- Effect level:
- > 60 mg/kg bw/day
- Sex:
- female
- Basis for effect level:
- other: no adverse effects observed at doses up to 60 mg/kg bw/day administered ip for 14 consecutive days.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No data about the effects of 4 -VP on body weight, clinical signs and serum sorbitol dehydrogenase were given.
No histopathological effects of 4 -VP were found in the lungs or liver of the rats (see table.)
Histopathological lesions
Dose [mg/kg/d] (a) |
|||||
0 |
2 |
6 |
20 |
60 |
|
Number examined |
5 |
5 |
5 |
5 |
5 |
Liver, fatty change, portal |
2 |
0 |
4 |
2 |
1 |
Lung, foam cells |
0 |
1 |
0 |
0 |
0 |
(a) Doses were administered as 3 equally partial doses at 0, 2, and 4 h for 14 consecutive days.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.