Bis(2-ethylhexan-1-olato)bis(pentane-2,4-dionato-O,O')titanium

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1989

Reference 2

Reference Type:

publication

Title:

2-Ethylhexanol

Author:

BG-Chemie

Year:

1995

Bibliographic source:

Toxikologische Bewertungen, Programm zur Verhütung von Gesundheitsschädigungen durch Arbeitsstoffe

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

not specified

Test type:

traditional method

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexan-1-ol

EC Number:

203-234-3

EC Name:

2-ethylhexan-1-ol

Cas Number:

104-76-7

Molecular formula:

C8H18O

IUPAC Name:

2-ethylhexan-1-ol

Test animals

Species:

rat

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: mixture of vapour and aerosol / mist

Type of inhalation exposure:

whole body

Vehicle:

air

Duration of exposure:

ca. 4 h

Concentrations:

5.3 mg/L (group I). 0.89 mg/L (group II)

No. of animals per sex per dose:

3

Details on study design:

Duration of observation period following administration: 7 days

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

>= 0.89 - <= 5.3 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Mortality:

Group I (5.3 mg/L): all died.
Group II (0.89 mg/L) : none died.

Clinical signs:

other: Group I: One male and one female died during exposure after signs of respiratory distress, nasal discharge, chromodacryorrhea (blood tears), closed eyes and feebleness. Group II: all rats survived exposure and observation period with no notable effects.

Gross pathology:

Not carried out.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

LC50 value was between 0.89 and 5.3 mg/l. The substance was classified as category 4 according to GHS

Executive summary:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.