Bis(2-ethylhexan-1-olato)bis(pentane-2,4-dionato-O,O')titanium

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

GLP compliance:

no

Remarks:

The hydrolysis rate is too fast and rigorous guideline test is not possible.

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Supplier: Borica Co., Ltd.
- Lot number: 200520P
- Expiration date of the lot/batch: 2018-Feb-19
- CAS number: 94233-27-9

Radiolabelling:

no

Analytical monitoring:

yes

Details on sampling:

- Sampling intervals for the parent/transformation products: The concentration of test substance in the test sample was determined at time points between 0 & 60 minutes based on quantification of the hydrolysis product. Sampling point: 0, 5, 10, 25, 40, 60 min.
- Sampling method: The test was performed at 30°C. An amount of test substance (above the water solubility) was added to the buffer solution. The amount of hydrolysis products formed was determined as function of time. The test was performed in duplicate. At each sampling time, samples were taken from each test and analyzed in duplicate.

Buffers:

- pH: 1.2, 4, 7 and 10
Conc. 0.01 M
pH 1.2 HCl
pH 4 Acetate
pH 7 Phosphate
pH 10 Borate

Duration:

60 min

pH:

1.2

Temp.:

30 °C

Duration:

60 min

pH:

4

Temp.:

30 °C

Duration:

60 min

pH:

7

Temp.:

30 °C

Duration:

60 min

pH:

10

Temp.:

30 °C

Number of replicates:

2

Positive controls:

no

Negative controls:

yes

Remarks:

(Blank buffer solutions)

Preliminary study:

The hydrolysis products (transformation products) were identfied.

Transformation products:

yes

No.:

#1

No.:

#2

No.:

#3

Details on hydrolysis and appearance of transformation product(s):

The solution immediately became cloudy and white precipitation forms when water was added into the Test Substance, indicating the rapid hydrolysis behavior of the Test Substance.

Key result

pH:

1.2

Temp.:

30 °C

DT50:

<= 30 min

Key result

pH:

4

Temp.:

30 °C

DT50:

<= 30 min

Key result

pH:

7

Temp.:

30 °C

DT50:

<= 30 min

Key result

pH:

10

Temp.:

30 °C

DT50:

<= 30 min

Validity criteria fulfilled:

yes

Conclusions:

The hydroylsis half-life of the test subsatnce was less than 30 minute.

Executive summary:

The hydrolysis (transformation) products were identified. hydrolysis products of the test substance include: 2-ethylhexanol, pentane-2,4 -dione and 2-ethylhexyl acetate.

2-ethylhexanol and pentane-2,4 -dione were the ligands binding to the original test substance. 2-ethylhexyl acetate was considered to be the side product formed during manufacturing.

The substance was tested for hydrolysis rate study, under 4 pH values – 1, 4, 7, 10, and 1 temperature – 30°C, according to OECD guideline 111. The formation of hydrolysis product – 2-ethylhexanol was monitored using GC-MS with respect to hydrolysis time. The formation of 2-ethylhexanol levels of within 10 minutes at 4 different pHs. It was safely concluded that the hydrolysis half-life was less than 30 minutes at pH 1, 4, 7, 10 and under 30°C.

Based on this study, the test substance was considered rapidly hydrolyzable.

Description of key information

Test conducted according to OECD guideline 111.

Key value for chemical safety assessment

Half-life for hydrolysis:

30 min

at the temperature of:

30 °C

Additional information

The substance was tested for hydrolysis rate study, under 4 pH values – 1, 4, 7, 10, and 1 temperature – 30°C, according to OECD guideline 111. The formation of hydrolysis product – 2-ethylhexanol was monitored using GC-MS with respect to hydrolysis time. The formation of 2-ethylhexanol levels of within 10 minutes at 4 different pHs. It was safely concluded that the hydrolysis half-life was less than 30 minutes at pH 1, 4, 7, 10 and under 30°C.

Based on this study, the test substance was considered rapidly hydrolyzable.