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EC number: 276-380-9
CAS number: 72140-65-9
The acute oral lethality of the test article was determined in
rats. Female Wistar rats received 300 mg/kg (6 females) or 2000 mg/kg (3
females) test article dissolved in DMSO via oral gavage. Observations
for mortality (recorded twice daily), body weights (day 1, 8, 15 or at
death), clinical signs (once daily), and macroscopic examination (at
necropsy). At 2000 mg/kg all animals exhibited clinical signs of
toxicity including lethargy (3/3), spasms (3/3), abnormal and/or hunched
posture (3/3), abnormal gait (3/3), uncoordinated movements (2/3),
ventro-lateral recumbency (1/3), loss of righting reflex (1/3),
increased activity (1/3), hypotonia (1/3), deep breathing (1/3),
piloerection (3/3), shaking head (1/3), paleness (1/3), salivation
(1/3), dehydration (2/3), and ptosis (3/3). On Day 2 one animal in the
2000 mg/kg group was euthanized for humane reasons after exhibiting
symptoms including lethargy, tremors, and pale and lean appearance.
Another animal was found dead on Day 4 in this dose group. These two
animals had reduced spleen sizes, and gastrointestinal distension upon
post mortem examination. At the 300 mg/kg animals exhibited piloerection
and hunched posture (6/6), lethargy (3/6), ptosis (3/6), rales (1/6),
and slow breathing (1/6) between Days 1 and 8. No mortality was seen at
this dose level, however, and only one animal had gastrointestinal
distention due to gas noted on necropsy. Based on the results of
the study, the rat oral LD50 of the test article is between 300 -2000
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