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EC number: 276-380-9
CAS number: 72140-65-9
The dermal irritation potential of MTDID 15670 (unknown form, lot
unknown) was evaluated in rabbits. The study design was based on the
recommendations in US CFR Title 16, Section 1500.41. Six hair clipped
rabbits received test material on one abraded and one intact test site.
The test material was held in place with 1 inch x 1 inch gauze, adhesive
tape, and an impervious material such as rubberized cloth was wrapped
around the torso of the rabbit. After 24 hours of exposure the patches
were removed and the sites were scored for erythema and edema (0-4
scales). Observations are recorded at 24 and 72 hours after the exposure
period and the scores of all sites are averaged together to produce the
primary dermal irritation index (PDII) . Animals were not observed
beyond 72 hours after exposure. Erythema (scores: 2-3) and edema
(scores: 1-3) were observed at all treated sites at both observation
times. Blanching of the skin was observed in intact sites (4 animals)
and abraded sites (5 animals) at 24 hours post-exposure. Blanching and
cracked skin was observed in 3 animals at 72 hours post-exposure. The
PDII was 5.0. Based on the results of this study, MTDID 15670 is a
moderate skin irritant.
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