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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation / corrosion, other
Remarks:
information taken from dermal toxicity study
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
information taken from dermal toxicity study

Data source

Reference
Reference Type:
review article or handbook
Title:
GESTIS Substance Database 1,3-Dichloropropane
Author:
IFA Institue for Occupational Safety and Health of the German Social Accident Insurance
Year:
2018
Bibliographic source:
http://gestis-en.itrust.de/pdf/create/Data_sheet.php

Materials and methods

Principles of method if other than guideline:
Observation from dermal toxicity study: 2000 mg/kg occlusive on the skin for 24 h without effect (post incubation observation period14 d)
GLP compliance:
no
Remarks:
Reliable data from handbook or collection of data but without specification of method. GLP not specified but quality is assumed to be similar to GLP

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dichloropropane
EC Number:
205-531-3
EC Name:
1,3-dichloropropane
Cas Number:
142-28-9
Molecular formula:
C3H6Cl2
IUPAC Name:
1,3-dichloropropane
Test material form:
liquid
Specific details on test material used for the study:
no data available

In vitro test system

Vehicle:
unchanged (no vehicle)
Amount/concentration applied:
2000 mg/kg bw
Duration of treatment / exposure:
24 h
Duration of post-treatment incubation (if applicable):
post incubation observation period 14 d

Test animals

Species:
rat
Strain:
not specified
Details on test animals or test system and environmental conditions:
data available in data bank

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
2000 mg/kg bw
Duration of treatment / exposure:
24 h
Observation period:
14 d
Number of animals:
unknown

Results and discussion

In vitro

Results
Irritation / corrosion parameter:
other: score of up to 10
Remarks:
10 is highest score = corrosive
Value:
2
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified
Other effects / acceptance of results:
dernal toxicity test: no fatalities

In vivo

Irritant / corrosive response data:
Category 3 (mild irritant) based on GHS criteria

Applicant's summary and conclusion

Interpretation of results:
Category 3 (mild irritant) based on GHS criteria
Conclusions:
Worst case: Category 3 (mild irritant) based on GHS criteria (result to be checked in regard to classification)