Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-531-3 | CAS number: 142-28-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- GESTIS is reliable data source
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- GESTIS Substance Database 1,3-Dichloropropane
- Author:
- IFA Institue for Occupational Safety and Health of the German Social Accident Insurance
- Year:
- 2 018
- Bibliographic source:
- http://gestis-en.itrust.de/pdf/create/Data_sheet.php
- Reference Type:
- review article or handbook
- Title:
- Toxicology of the Eye. 3rd ed.
- Author:
- Grant, W.M.
- Year:
- 1 983
- Bibliographic source:
- 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 1030
Materials and methods
- Principles of method if other than guideline:
- Rats were administered undiluted doses of 2000 mg per kg of body weight over 24 hours on shaved dorsal skin in order to examine the dermal toxicity.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,3-dichloropropane
- EC Number:
- 205-531-3
- EC Name:
- 1,3-dichloropropane
- Cas Number:
- 142-28-9
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,3-dichloropropane
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- doses of 2,000 mg per kg of body weight over 24 hours on shaved dorsal skin
- Duration of exposure:
- 24
- Doses:
- 2000 mg/kg
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no fatalities within 2 weeks of observation period
- Clinical signs:
- other: toxicity symptoms reported not to have occured
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- dermal acute toxicity is low
- Executive summary:
dermal LD50 (occlusive, rat) 2000 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
