Registration Dossier
Registration Dossier
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EC number: 406-690-3 | CAS number: 43136-14-7 MDI/ODA
Endpoint summary
Administrative data
Description of key information
A short-term repeat oral toxicity study was conducted with the test item over 28 days with 7 days/week dosing at three concentrations up to 1000 mg/kg bw/day. No treatment related findings were observed at any of the nominal concentrations tested and therefore the NOAEL and NOEL was determined to be 1000 mg/kg/b.w. day.
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- The study is a guideline study and has been submitted previously for regulatory purposes; and therefore it is deemed acceptable for evaluation.
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
In the study conducted with the test item it was concluded that the test item should not be classified. Additionally, the test item does not have a harmonised classification for repeat dose toxicity.
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